Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function
نویسندگان
چکیده
منابع مشابه
Enhanced β2-adrenergic receptor (β2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer
BACKGROUND Beta2-adrenergic receptors (beta2AR) play important regulatory roles in a variety of cells and organ systems and are important therapeutic targets in the treatment of airway and cardiovascular disease. Prolonged use of beta-agonists results in tolerance secondary to receptor down-regulation resulting in reduced therapeutic efficiency. The purpose of this work is to evaluate the signa...
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Typically phospholipids in cell membranes are not symmetrically distributed between the inner and outer leaflets. The resulting asymmetry is crucial in several cellular functions, such as apoptosis and secretary vesicle formation and fusion. The rate of spontaneous phospholipid diffusion across the membranes is slow with half-times varying from hours to weeks. Still, a number of membrane protei...
متن کاملEnhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy approaches to alter cardiac function can be realized, efficient and reproducible in vivo gene techniques must be established to efficiently transfer transgenes globally to the myocardium. We have been testin...
متن کاملActivation mechanism of the β2-adrenergic receptor.
A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs, these structures do not reveal the mechanism by which GPCRs transition between these states. Here we propose an activation mechanism for the β(2)...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 1999
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3300940